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antimony and other antimony compounds, because (1) people can be exposed to antimony(III) trioxide resulting from transformation from other forms of antimony, and (2) studies of biological effects and other relevant information may inform understanding of antimony(III)
Background: Antimony (Sb) trioxide and antimony trisulfide are "2B: Possibly carcinogenic to humans" and "3: Unclassifiable" according to the International Agency for Research on Cancer (IARC). The U.S. National Toxicology Program (NTP) concluded that antimony trioxide "is reasonably anticipated to be a human carcinogen based on studies in rats and mice".
Aug 29, 1997· Occupational exposure to airborne antimony or antimony trioxide has resulted in dermatitis (epidermal cellular necrosis with inflammatory cellular reactions) and ocular irritation (ocular conjunctivitis), the effects being more pronounced in higher temperature environments (Stevenson, 1965; Potkonjak and Pavlovich, 1983).
Oct 01, 1996· Evidence for a carcinogenic risk of antimony in experimental animals was judged by the IARC sufficient for antimony trioxide and limited for antimony trisulfide. In man, IARC considered antimony trioxide as possibly carcinogenic.
Antimony: RoC Protocol i Table of Contents Introduction iii Objective iii Scope iii Key questions iii Background information iii Cancer hazard evaluation iv Protocol components iv 1 Outline of the Draft RoC Monograph 1 1.1 Substance chemical properties and human exposure 1 1.2 Human cancer studies 1 1.3 Experimental animal cancer studies 1 1.4 Mechanisms, toxicokinetics, and other relevant data 1
Sb 3+ compounds (particularly antimony trioxide and antimony trisulfide) are potential carcinogens. Sb 5+ compounds are not classical mutagens but act as carcinogens. Antimony compounds are reproductive toxicants and disrupt conception and increase the risk of spontaneous abortion. Clinical Signs
Jan 21, 2015· The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans (group 2B) and antimony trisulfide is not classifiable as to its carcinogenicity (group 3). Antimony has not been classified for cancer effects by the Department of Health and Human Services or the EPA.
May 28, 2013· However, if you come into contact with actual antimony dust, you can experience symptoms like depression, dizziness, headaches, vomiting, kidney damage, or liver damage. One compound antimony trioxide is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome.
regarding antimony exposure and cancer, while animal studies have reported lung tumors in rats exposed to antimony trioxide via inhalation. EPA has not classified antimony for carcinogenicity. Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS)
Safe Use and Responsible Management of SbThe International Antimony Association, or i2a for short, is the Brussels-based organisation that represents the producers, importers and users of Antimony. Our aim is a sustainable and responsible Antimony industry being achieved through product stewardship ensuring safe use and responsible management of Sb substances.
Antimony trioxide has been identified by the EPA as a suspected lung carcinogen. Historical studies have concluded that exposure to elevated levels of antimony oxide may cause lung carcinoma.
Antimony(III) oxide has suspected carcinogenic potential for humans. Its TLV is 0.5 mg/m 3, as for most antimony compounds. No other human health hazards were identified for antimony(III) oxide, and no risks to human health and the environment were identified from the production and use of antimony trioxide in daily life. References
Antimony trisulfide (Sb2S3) is used as a lubricant in friction material. X-ray diffraction analysis revealed Sb in 3/3 disc brake pads (range 41,00046,000 mg/kg) and in 2/2 disc brake dust samples (21,000 and 17,000 mg/kg) from trucks.
Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L. Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. J Toxicol Environ Health. 1986; 18 (4):607626. Newton PE, Bolte HF, Daly IW, Pillsbury BD, Terrill JB, Drew RT, Ben-Dyke R, Sheldon AW, Rubin LF.